The MEK results agree with earlier MEK experiments at comparable exposure conditions, and the MIBK results are consistent with a recent Swedish study that used MIBK exposures and showed no significant behavioral performance decrements from single MIBK exposures at 50 ppm with 50 W exercise. Prepared by the Office of Health and Environ- mental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. For many specific ketones, no data are available. Additionally, chemical measurements (blood and breath) and reports of sensory and irritant effects were measured. Methyl isobutyl ketone and methyl ethyl ketone in urine as biological markers of occupational exposure to these solvents at low levels. 1988 Oct;43(1-3):31-49. doi: 10.1016/0378-4274(88)90019-7. 0.2.1.1 ACUTE EXPOSURE. Kawai T, Zhang ZW, Takeuchi A, Miyama Y, Sakamoto K, Higashikawa K, Ikeda M. Int Arch Occup Environ Health. POTENTIAL PHYSICAL / CHEMICAL EFFECTS Flammable. An interaction occurred between gender and alcohol ingestion, such that more statistically significant performance decrements were found for females than for males. 2,5-Hexanedione has an effect on spermatogenesis in male experimental animals. They are a natural by-product of fatty acid metabolism and have industrial uses as solvents, polymer precursors and in pharmaceuticals. Truven Health Analytics Inc. makes no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the productsAdditionally, Truven Health ANALYTICS INC. makes no representation or warranties as to the opinions or other service or data you may access, download or use as a result of use of the Truven Health ANALYTICS INC. products. "�����^����:�{ĂWK�s�.雷�]&�Ѕ0��@{j·z��x��d�4Mq�JȬ1/�s�k��U��M���0߯AQ~�q�8C�cm��'XOi ��p�[��yr���DG��E�͛��C=ŶL���g�iQ�˟�>5�� Ethanol by ingestion (95%-0.84 ml/kg) was used as a positive control. Significant odor sensations and irritant effects were reported by the subjects during the chemical exposures. Get the latest research from NIH: https://www.nih.gov/coronavirus. Health and Environmental Effects Profile for Methyl Ethyl Ketone. Print. 2) OCULAR: Splash exposures of ketones to the eyes may cause varying degrees of irritation, depending on the ketone. Gas concentrations are in percent by volume. 3. These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. 3 0 obj FK����F�USouy���}�|�٣q9'�>�z���.|�?�cυC��N+C��(���. HAZARDS IDENTIFICATION This material is considered to be hazardous according to regulat ory guidelines (see MSDS Section 15). Truven Health Analytics Inc. does not assume any responsibility or risk for your use of the Truven Health Analytics Inc. products. Subjects were 68 males and 75 females recruited from local universities; ages ranged from 18 to 32 years. Behavioral methods and organic solvents: questions and consequences. Alcohol ingestion, however, produced significant decrements on every performance test except memory scanning and mood. �H]���>��b�j�� X� �ڑ�k�y�[�RJ�f��{����5��=���.`����J����)o'�F�o� S stream Dick RB, Brown WD, Setzer JV, Taylor BJ, Shukla R. Toxicol Lett. Neurobehavioral effects from acute exposures to methyl isobutyl ketone and methyl ethyl ketone. In part 1, the number of studies between the years 2000 to 2010 that have investigated the health effects of each chemical in specific medical categories Neurotoxic interactions of industrially used ketones. 1989 Feb;46(2):111-21. doi: 10.1136/oem.46.2.111. To scientifically substantiate the standards, a study was conducted on three groups of workers to … 2003 Feb;76(1):17-23. doi: 10.1007/s00420-002-0374-9. A) Experimental animal studies are limited, but are generally negative, and agents in this group have little mutagenic activity. They are a natural by-product of fatty acid metabolism and have industrial uses as solvents, polymer precursors and in pharmaceuticals. 1) INHALATION: Acute inhalation of ketones may cause varying effects, depending on the extent and duration of exposure. The information contained in the Truven Health Analytics Inc. products is intended as an educational aid only. 6 0 obj 0.2.1 SUMMARY OF EXPOSURE. be exposed to. ���+���|�/��]������U缆��V0�>�F=�R�Ay(�L���d%5s���ߟx�������D���)��u�6D�IR� =�U���x_ H8� Get the latest public health information from CDC: https://www.coronavirus.govGet the latest research information from NIH: https://www.nih.gov/coronavirus, PDF documents can be viewed with the free Adobe® Reader. Health Effects Assessment for Methyl Ethyl Ketone. Exposure of rats to methyl ethyl ketone at a level of 200 ppm, 12 hours/ day, 7 days/week for 24 weeks resulted 1n slight neurological effects visible only at 4 months of treatment (Takeuchl et al., 1983), but exposure of rats to 1125 ppm continuously for 5 months did not result In neuropathy, defined 1n terms of paralysis (Salda et al., 1976).

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