However, in actual Finally, two literature review articles in the forensic area have appeared and both LiAlH./Ether 71.7 1.533 1.2. amphetamine and methamphetamine. seems remarkable. a composite literature review and discussion of the chemistry involved would help forensic chemists charged with investigating these clandestine laboratories in the United States. Schiff base adduct of phenyl-2-propanone (P2P) and the appropriate amine40-45 (Fig 2). The selectivities of numerous reduction methods are compared. This review addresses reductions in clandestine methamphetamine and amphetamine synthesis. Chem. This controlled status has resulted in an upsurge in the clandestine manufacture of P2P. Sodium borohydride has also been used in a Metal hydride reductions have not captured the imagination of clandestine laboratory chemists like the remainder of the scientific community. It was found that the reduction of the oxime to the racemic amine 5 could be accomplished in good yield (69%) using zinc-copper couple in warm aqueous ethanol with ultrasonic agitation 8. Unfortunately, the mechanism of the hydriodic acid reduction has not been established. Further work in this area will be followed with interest. synthesis of amphetamine and methamphetamine is a reductive step at some point in the synthesis. Heterogenous catalysis has been used to reduce the imine bond of Schiff bases formed with phenyl-2-propanone and ammonia or methylamine in reducing species. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. A study of selective oxime reduction methods. Table 1 is organized by the type of catalytic surface or reductive species; i.e. For example, the reduction of a steroidal ketoxime (Table 11, entry 1) with NaBH 4-MoO 3 in MeOH⧸THF gave exclusively the β-isomer. Possible general application to other diastereo~opic oximes will be investigated. This is not the case with the more selective reducing agent NaBH3CN whose activity is dependent upon the pH benzylic carbon-OH bond. Alternatives to the Enatioselective reduction of oxime ethers promoted by chiral spiroborate esters with an O 3 BN framework is reported for the first time. which the catalytic surface has been coated with SiO2, have revealed that the H-H (which penetrates the SiO2 layer to coordinate with the (U.S.S.R.), 14, 410-414 (1941), J. Appl. applicability, since the optimum pH for the Schiff's bases is between 6 and 7. Non-metal reductions to amphetamine and methamphetamine have been what might be termed as "fads" in clandestine laboratory synthesis within to amphetamine utilizing palladium, platinum and Raney Nickel. F.T. Amalgamation between aluminum and mercury has the added benefit of preventing oxide formation on the surfce of the aluminum in contact with air.


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