Practical applicability was demonstrated in a gram-scale biotransformation. The Journal of Organic Chemistry 2010 , 75 (6) , 1961-1966. Preparation of Ethers by Dehydration of Alcohols In the presence of protic acids ( sulphuric acid ), alcohols undergo dehydration to produce alkenes and ethers under different conditions. Practical applicability was demonstrated in a gram-scale biotransformation. In the conversion of primary alcohols to primary amines R − C H X 2 O H ⟶ R − C H X 2 N H X 2 direct alkylation of ammonia normally is the last thing you want to do in the lab. Copyright © 1995 Published by Elsevier Ltd. https://doi.org/10.1016/0040-4039(95)02046-2. The optimized E. coli/ADH-AmDH strains produced enantiopure amines from the alcohols with up to 80% conversion and a molar productivity up to 15 mM. For aromatic amines, selective N-monomethylation and selective N,N-dimethylation were accomplished. Fetching data from CrossRef. Grignard reaction with aldehydes and ketones. α-Chiral amines are pivotal building blocks for chemical manufacturing. Higher concentrations of certain amine products resulted in toxicity and cell death, which could be alleviated by the addition of a co-solvent. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The interactions between the gold nanoparticles, DNA, and water lead to high catalytic efficiency under mild reaction conditions. The optimized E. coli/ADH-AmDH strains produced enantiopure amines from the alcohols with up to 80% conversion and a molar productivity up to 15 mM. This preparation method applies in case of conversion of volatile alcohols to aldehydes. Fujita, Synthesis, 2018, 50, 4617-4626. In the Gabriel synthesis, potassium phthalimide is reacted with an alkyl halide to produce an N‐alkyl phthalimide. to access the full features of the site or access our. Abstract Secondary or tertiary amines may be prepared from primary alcohols and primary or secondary amines by treating triphenylphosphine with N-bromosuccinimide (NBS) in the presence of the alcohol at low temperature, followed by addition of the amine and heating for about 1 h. and it is not used for commercial purposes. This article is licensed under a Creative Commons Attribution-NonCommercial • Reproduced material should be attributed as follows: Information about reproducing material from RSC articles with different licences f.mutti@uva.nl. For reproduction of material from all other RSC journals. Stereoselective amination of alcohols is receiving increased interest due to its higher atom-efficiency and overall improved environmental footprint compared with other chemocatalytic and biocatalytic methods. A. Houwman, T. Knaus, M. Costa and F. G. Mutti, Van ‘t Hoff Institute for Molecular Sciences, HIMS-Biocat, University of Amsterdam, Science Park 904, 1098 XH, The Netherlands, Creative Commons Attribution-NonCommercial

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